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In the year 2060, violence rules the streets of Seattle and a conspiracy is hatched to spread a plague of vampirism. When Rachel Meyer's boyfriend Warren Storey is abducted by these conspirators, she hires shadowrunners to find Warren and bring him back. But the runners uncover a plot by Dr. Oslo Wake to transform all metahumans into walking dead. For Dr. Wake is developing a new strain of the virus that causes vampirism. The strain is far from perfected. Now, Warren has become a test subject in a medical procedure to create these unstoppable creatures. It's up to Rachel and her vampire hunter friends to rescue him.