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By 2018, America has been ravaged by terrorism and biological warfare. One particular bio-weapon, dubbed the "Wrath of God," has virtually destroyed the nation - infecting its victims with wildly varying symptoms and creating horrifying genetic mutations. Those who survive the plague fight for life day to day, struggling to maintain a semblance of society. Rebecca Artemis has been infected by "the Wrath" in an astonishingly macabre way. Like a vampire, she feeds upon blood to maintain her own deteriorating blood cells. Consumed by guilt over the atrocities she commits, she feverishly seeks to regain her faith and humanity. Making matters worse, Rebecca's condition is exploited by the evil "Reverend," who forces her to commit unspeakable acts of violence for his own amusement. For Rebecca, death may be the only escape from the evil surrounding her, but how many others will perish in rivers of blood along her path to redemption?